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Mitral Regurgitation


Approximately 40% of patients with chronic systolic heart failure have moderate to severe mitral regurgitation (MR). Inpatient populations have an even higher rate. One study estimated it at 63%. In heart failure patients with an LVEF < 40%, moderate to severe MR is a predictor of mortality.

There are two primary varieties of MR: degenerative and functional. Degenerative MR is due to disease of the valve itself. Functional MR is primarily due to myocardial disease. The distortion or enlargement of the left ventricle and its impact on the muscles supporting the mitral valve leaflets stretches the valve opening so that it fails to close. Left untreated, functional MR adds to myocardial stress and can lead to or accelerate the progression of heart failure.

This page is intended to be a resource to all clinicians involved in the care of patients with heart failure who would like to know more about the management of MR. Resources currently available:

  • A bibliography and annotated key articles on valvular disease and MR
  • Guideline statements on the management of MR
  • Case Studies
  • News Updates

This educational initiative is supported by an unrestricted educational grant from Abbott Vascular.


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