Home / Industry News / Detailed findings from CAROLINA® outcome trial support long-term cardiovascular safety profile of Tradjenta®


Ridgefield, Conn. and Indianapolis, June 10, 2019 – Boehringer Ingelheim and Eli Lilly and Company (NYSE: LLY) announced detailed findings from the CAROLINA® trial demonstrating that Tradjenta® (linagliptin) did not increase cardiovascular risk compared with glimepiride in adults with type 2 diabetes and cardiovascular risk. The findings were reported today at the American Diabetes Association’s 79th Scientific Sessions® in San Francisco.

The trial met its primary endpoint, defined as non-inferiority for Tradjenta versus glimepiride in time to first occurrence of cardiovascular death, non-fatal myocardial infarction or non-fatal stroke (3P-MACE), which occurred in 11.8% (356 people) of the Tradjenta group compared with 12.0% (362 people) of the glimepiride group. The overall safety profile of Tradjenta in CAROLINA was consistent with previous data, and no new safety signals were observed.

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